TWIN PREGNANCY

Twin pregnancies in 1 out of every 80 pregnancies that occur naturally. This rate increases even more in those who receive drug therapy for pregnancy and especially in IVF studies.
Twins are divided into single twins (monozygotic) and fraternal twins (dizygotic). Monozygotes are also called "identical" and dizygotes are called "fraternal". One tenth of all twins are monozygotic twins.
Dizygotic twins (fraternal twins): Two egg cells are fertilized at the same time by 2 sperms. Their genetic makeup is not the same, so their sex and appearance may be different. They are like two separate brothers who are in the mother's womb at the same time.
There are always two placentae in them. The placenta and amnions are different.
Monozygotic twins (identical twins): Like single pregnancies, 1 egg is fertilized by 1 sperm, but will be divided later. The genders are always the same. Their genetic structure is the same. If this division occurs within the first 3 days after fertilization, diamniotic dichorionic (two amniotic sacs, two pleenta), diamnionic monochorotic (two amniotic sacs, one pleenta), and monoamniotic monochorionic (single amniotic sacs) between 9-13 days. single placenta) becomes twin pregnancy. The most common diamniotic is monochorionic. Siamese twins (conjoined twins) are formed as a result of divisions after the 13th day.
It is very important to have one or two (monochorionic-dichorionic) plesentas in the follow-up of twin pregnancies. Ultrasound performed around 11-15 weeks can be very useful for differentiation.
Increased risks in multiple pregnancies:
- Miscarriage risk is higher.
- Preterm birth is more common.
- Preeclampsia and ectopia are more common during pregnancy.
- Nausea and vomiting are more common.
- Placenta anomalies are more common. Plesenta previai detachment plesenta.
- Anemia is more common.
- Congenital (congenital) anomaly risk is higher (even more in monozygotics)
- Serabral palsy (spastic handicapped) baby is more common.
- Twin to twin transfusion syndrome can be seen.
- Vanishing twin syndrome can be seen.
- Monoamniotic twins have a high risk of cord entanglement and related intrauterine death.
Who is more likely to have twin-triple pregnancy?
- It is more common in some races (about 5% in Nigeria)
- In pregnancies occurring in advanced ages (peaking at 37 years of age): It is more difficult to conceive at these ages compared to young ages, but when conceiving, the rate of majority pregnancy is high.
- If the mother has a family history of twin pregnancies, the chance increases (valid for dizygotic twins)
- Having a twin in the father's family does not affect.
- Multiparite
- In countries exposed to daylight, in summer
- In tall and overweight women
- Clomiphene citrate (about 10%) or in those who become pregnant with gonadotropin treatment (20-30%)
- The chance of forming monozygotic (twin egg) twins is not affected by any factor.
Normal or cesarean birth ?
Normal or cesarean delivery decision may change according to examination findings.
In pregnancies with more than two babies, cesarean is always preferred.
What is fetal reduction?
Fetal reduction is an attempt to reduce the number of fetuses to reduce certain risks, such as preterm birth, low birth weight, and multiple pregnancies in pregnancies with 3 or more fetuses in the uterus. For this, the substance called potassium chloride (KCl) is given to the heart of one or more of the fetuses via ultrasound via a fine needle from the mother's abdomen. The fetus whose heart is standing shrinks over time (may be 4-5 weeks) and disappears. The procedure is not harmful to other babies. In 4-5% of pregnancies treated, there is a risk of pregnancy leading to complete abortion with all fetuses.
The best time for this procedure is between 10-12 weeks of gestation. The reason for not being able to be done in earlier weeks is "to wait for the spontaneous termination of pregnancies if the development potential is low or may end spontaneously." In the next weeks, if one or two of the babies see a special problem and is thought to be incompatible with life, this process is applied.
One of the twins being dead and the other alive - Intrauterine death of the twin partner (Twin partner ex)
When one of the twins dies in the womb. It is seen in 3-5% of twin pregnancies. If one of the babies is dead, it may pose some risks for the alive baby.
In this case, especially if the twins are monochorionic (if the two babies have a single common placenta), the risk is higher for the live baby. Serious neurological damage occurs 3-4 times more in living baby than dizygotic twins. It is difficult to decide when to give birth. Conditions such as how old the live baby is and whether it has completed its development affect this decision. Whether twins are monochorionic (two babies have a single placenta) or dichorionic (two babies have separate placenta) is a criterion that will affect the decision of birth. Just because one of the twins is dead doesn't always mean that the live baby should be delivered immediately. The decision may vary depending on the obstetric condition in that patient. However, the baby who lives in monochorionic twins is delivered at high risk because it is at higher risk. In dichorionic twins, since the risk of harm to the living baby is low, birth may be delayed more if necessary.
ADDITIONAL INFORMATION:
- Valementous insertion (memrenous insertion) is more common in twin pregnancies in the placenta.
- It is seen in TTTS and TRAP monozygotic twins.
- Fetus papyraceus is a condition that can be seen in both monozygotic and dizygotic twins. It is the death of one of the fetuses before birth and being flattened by crushing.
- The average gestation period in single pregnancies is 39 weeks, while it is 35 in twins, 32 in triplets and 29 in quadruplets.
- In twin pregnancies, B-HCG, AFP, Estradiol, Estriol, progesterone levels are higher than normal pregnancies.
 In twin pregnancies, preterm labor (preterm delivery), PPROM, GDM (gestational diabetes), preeclampsia, anemia, detachment placenta, uterine atony, placenta previa, postpartum hemorrhage are more common than single pregnancies.
- Some of the physiological changes that occur in every pregnancy occur more seriously in twin pregnancies. For example, increased blood volume in the mother and anemia are more in twin pregnancies. Cardiac output increases more than single pregnancies. The need for iron and folic acid increases more.
- About 80% of women diagnosed with twin pregnancy in the first months of pregnancy have twin babies. The other part gives birth to a single baby due to the disappearance of one of the fetuses in the first triemster.
- Presentation in twin pregnancies at birth is most frequently observed as vertex-vertex (40%). Then, vertex-breech (25%) and vertex-transverse (20%) are observed, respectively.

-TWIN PREGNANCY
-WHAT SHOULD BE DONE TO HAVE TWIN PREGNANCY?
-IDENTICAL TWINS
-FRATERNAL TWINS
-TRIPLET PREGNANCY
-NORMAL BIRTH OR CESAREAN IN TWIN PREGNANCIES?
-TWIN TO TWIN TRANSFUSION SYNDROME
-CAN THERE BE TWIN BABIES FROM DIFFERENT FATHERS?
-CAN ANOTHER PREGNANCY OCCUR DURING PREGNANCY?
-VANISHING TWIN SYNDROME
-FETUS IN FETU (FIF)
-CHIMERISM

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